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- Title
Evolution of the amniotic sac and extracelomic space as seen by early ultrasound examination.
- Authors
Santolaya-Forgas, Joaquin; De Leon-Luis, Juan; D'Ancona, Roberto Levy; Morgan, Jeffrey; Kauffman, Robert P.
- Abstract
<bold>Objective: </bold>Amniotic sac and extracelomic space changes occurring from 5 to 14 weeks of pregnancy were observed with transvaginal ultrasound to gain new insights into their normal relationships during this time period.<bold>Study Design: </bold>Ninety-seven women from 5 to 15 weeks' gestation were enrolled in the study. Gestational age was determined by measuring embryonic crown-rump length. The embryo, amniotic sac, and gestational sac areas were measured using the best-fitted computer-generated elliptical view. The embryonic heart rate was measured using the M-mode function of the ultrasound equipment. Associations were determined using the least-squares method and Pearson's correlation coefficient.<bold>Results: </bold>Mean (range) gestational age calculated from CRL was 9.6 (5.3-14.6) weeks, embryonic heart rate 153 (100-188) beats per minute, embryonic surface 699.6 (5-2,199) mm(2), amniotic sac surface 1,383 (5-5,335) mm(2) and gestational sac surface was 1,517 (110-5,335) mm(2). Significant correlations between gestational sac surface, amniotic sac surface, embryonic surface, heart rate and gestational age were noted (p < 0.01). Changes in the amniotic sac surface correlated with embryonic surface but not with heart rate even when multiple regression analysis was attempted.<bold>Conclusion: </bold>These data describe the normal relationships between the embryonic, amniotic sac, extracelomic space, and gestational sac surface, suggesting that increases in embryonic surface area is a determining factor for early expansion of the amniotic sac at these gestational ages.
- Subjects
ULTRASONIC imaging; PREGNANCY; EMBRYOLOGY; FETAL heart; MULTIPLE regression analysis; AMNION; COMPARATIVE studies; FETAL ultrasonic imaging; RESEARCH methodology; MEDICAL cooperation; REGRESSION analysis; RESEARCH; EVALUATION research
- Publication
Fetal Diagnosis & Therapy, 2003, Vol 18, Issue 4, p262
- ISSN
1015-3837
- Publication type
journal article
- DOI
10.1159/000070807