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- Title
Signal transduction and endocytosis: close encounters of many kinds.
- Authors
Sorkin, Alexander; von Zastrow, Mark
- Abstract
Binding of hormones, growth factors and other cell modulators to cell-surface receptors triggers a complex array of signal-transduction events. The activation of many receptors also accelerates their endocytosis. Endocytic transport is important in regulating signal transduction and in mediating the formation of specialized signalling complexes. Conversely, signal-transduction events modulate specific components of the endocytic machinery. Recent studies of protein tyrosine kinases and G-protein-coupled receptors have shed new light on the mechanisms and functional consequences of this bidirectional interplay between signalling and membrane-transport networks.
- Subjects
CELLULAR signal transduction; ENDOCYTOSIS; PROTEIN-tyrosine kinases; CELL receptors; CELL physiology; ACTIVE biological transport
- Publication
Nature Reviews Molecular Cell Biology, 2002, Vol 3, Issue 8, p600
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm883