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- Title
Immune defence against Candida fungal infections.
- Authors
Netea, Mihai G.; Joosten, Leo A. B.; van der Meer, Jos W. M.; Kullberg, Bart-Jan; van de Veerdonk, Frank L.
- Abstract
The immune response to Candida species is shaped by the commensal character of the fungus. There is a crucial role for discerning between colonization and invasion at mucosal surfaces, with the antifungal host defence mechanisms used during mucosal or systemic infection with Candida species differing substantially. Here, we describe how innate sensing of fungi by pattern recognition receptors and the interplay of immune cells (both myeloid and lymphoid) with non-immune cells, including platelets and epithelial cells, shapes host immunity to Candida species. Furthermore, we discuss emerging data suggesting that both the innate and adaptive immune systems display memory characteristics after encountering Candida species.
- Publication
Nature Reviews Immunology, 2015, Vol 15, Issue 10, p630
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri3897