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- Title
T cell differentiation: Inhibiting T<sub>H</sub>17 cells.
- Authors
Bell, Elaine
- Abstract
The article highlights a study which found that halofuginone is a specific inhibitor of T cell differentiation and acts by activating the amino acid starvation response (AAR). The authors of the study found that halofuginone can impair the TH17 cell differentiation and interleukin-17 (IL-17) expression. It was also observed that the genes that were upregulated following halofuginone treatment were associated with amino acid transport and biogenesis.
- Subjects
T cell differentiation; CELL differentiation; INTERLEUKINS; AMINO acids; MORPHOGENESIS
- Publication
Nature Reviews Immunology, 2009, Vol 9, Issue 7, p460
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2601