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- Title
T-cell memory: Growing with experience.
- Authors
Leavy, Olive
- Abstract
The article presents a study which examined how the pre-existing population of the CD8 + T cells are affected by the generation of the same. Naive CD8 + T cells specific for immunodominant epitope of lymphocytic choriomeningitis virus were transferred to naive mice, and new memory T cells specific for the N peptide of vesicular stomatitis virus were induced. The results show that effector memory T cell compartment is not fixed, but can adapt to immunological experiences.
- Subjects
T cells; VESICULAR stomatitis; LYMPHOCYTIC choriomeningitis; PEPTIDES; EPITOPES; LABORATORY mice
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 12, p905
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri2463