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- Title
Capping protein regulators fine-tune actin assembly dynamics.
- Authors
Edwards, Marc; Zwolak, Adam; Schafer, Dorothy A.; Sept, David; Dominguez, Roberto; Cooper, John A.
- Abstract
Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates actin assembly by blocking the addition and loss of actin subunits. Recent studies provide new insights into how CP and barbed-end capping are regulated. Filament elongation factors, such as formins and ENA/VASP (enabled/vasodilator-stimulated phosphoprotein), indirectly regulate CP by competing with CP for binding to the barbed end, whereas other molecules, including V-1 and phospholipids, directly bind to CP and sterically block its interaction with the filament. In addition, a diverse and unrelated group of proteins interact with CP through a conserved 'capping protein interaction' (CPI) motif. These proteins, including CARMIL (capping protein, ARP2/3 and myosin I linker), CD2AP (CD2-associated protein) and the WASH (WASP and SCAR homologue) complex subunit FAM21, recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.
- Subjects
CAPPING proteins; ACTIN; PHOSPHOLIPIDS; VASODILATOR-stimulated phosphoprotein; PROTEINS; MYOSIN
- Publication
Nature Reviews Molecular Cell Biology, 2014, Vol 15, Issue 10, p677
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm3869