We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic risk factors for infection in patients with early rheumatoid arthritis.
- Authors
Hughes, L B; Criswell, L A; Beasley, T M; Edberg, J C; Kimberly, R P; Moreland, L W; Seldin, M F; Bridges, S L
- Abstract
We analyzed clinical and genetic factors contributing to infections in 457 subjects with early rheumatoid arthritis (RA) enrolled in a prospective, 1-year clinical trial of methotrexate and the TNF inhibitor etanercept. Subjects were genotyped for the following single nucleotide polymorphisms (SNPs): (TNF-308,-238, and+488); lymphotoxin-a(LTA) (LTA+249,+365, and+720); and Fc gamma receptors FCGR2A 131 H/R; FCGR3A 176 F/V; and FCGR3B NA 1/2 and genotypes were correlated with infections. At least one URI was noted in 52%of subjects (99/191) with the NA2/NA2 genotype of the neutrophil-specific FCGR3B gene, compared to 42%(77/181) of those with the NA1/NA2 genotype and 39%(23/59) of those with the NA1/NA1 genotype (P=0.038). Urinary tract infection (UTI) was associated with the TNF-238 A (odds ratio(OR) 2.56, 95%confidence interval (CI) 1.05-6.25) and LTA+365 C (OR 1.73, 95%CI 1.07-2.79) alleles, and marginally with the FCGR3A F allele (OR 1.72, 95%CI 0.99-3.00). There was a striking linear correlation between UTI and the number of risk alleles defined by these three SNPs (P<0.001), suggesting an additive effect on susceptibility. These findings have important implications for the role of genetics in susceptibility to bacterial and viral infections.Genes and Immunity (2004) 5, 641-647. doi:10.1038/sj.gene.6364137 Published online 4 November 2004
- Subjects
RHEUMATOID arthritis; AUTOIMMUNE diseases; GENETICS; GENETIC polymorphisms; ETANERCEPT; METHOTREXATE
- Publication
Genes & Immunity, 2004, Vol 5, Issue 8, p641
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364137