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- Title
Substance Use and Early Psychosis Course.
- Authors
Tarricone, I.; Boydell, J.; Morgan, C.; Robin, M.; Di Forti, M.; Berardi, D.
- Abstract
Objectives Substance abuse is a well established risk factor for First-Episode Psychosis (FEP). We hypothesized that substance use at baseline could be an independent risk factorfor a worse clinical course. Methods An incidence cohort ofpatients with FEP collected in an 8 year period (2002-2009) at the Bologna WestCommunity Mental Health Centers (CMHCs) was assessed at baseline and at 12 month follow-up. Hospitalizations were used as clinical outcomes. Results Substance users had asignificantly higher rate of hospitalizations during the follow-up after adjusting for age, gender and other potential confounders (OR 5.84, 95% CI 2.44-13.97, p≤0.001). Conclusions This study showed the independent effect of substance use on FEP course. Clinical implications will be discussed. Tarricone I, Boydell J, Panigada S, Allegri F, Marcacci T, Minenna MG, Kokona A, Triolo F, Storbini V, Michetti R, Morgan C, Di Forti M, Murray RM, Berardi D. The impact of substance use at psychosis onset on First Episode Psychosis course: results from a 1 year follow-up study in Bologna. Schizophr Res. 2014 153(1-3):60-3. Allegri F, Belvederi Murri M, Paparelli A, Marcacci T, Braca M, Menchetti M, Michetti R, Berardi D, Tarricone I. Current cannabis use and age of psychosis onset: a gender-mediated relationship? Results from an 8-year FEP incidence study in Bologna. Psychiatry Res. 2013 Nov 30;210(1):368-70.
- Subjects
SUBSTANCE-induced disorders; PSYCHOSES; MENTAL health facilities; FOLLOW-up studies (Medicine); HOSPITAL care; DRUG synergism
- Publication
European Psychiatry, 2015, Vol 30, p1762
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1016/S0924-9338(15)31357-2