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- Title
Study of acute toxicity and antihypoxic activity of N<sup>4</sup>-substituted 5-(1,2,4-triazole-1-ylmethyl)-1,2,4-triazole-3-thiones.
- Authors
ZYKOVA, S. S.; TALISMANOV, V. S.; TSAPLIN, G. V.; BULATOV, I. P.; POPKOV, S. V.; KARMANOVA, O. G.; SAVINKOV, A. V.
- Abstract
The acute toxicity and antihypoxic activity of N4-substituted 5-(1,2,4-triazol-1-ylmethyl) -1,2,4-triazole-3-thiones were studied in mice during in vivo experiments. According to the test results, it was found that most of the compounds examined belong to the 5th class of toxicity (according to the OECD classification). Antihypoxic activity was investigated on the model of normobaric hypoxia with hypercapnia. The examined compounds demonstrated an average antihypoxic activity in comparison with the known antihypoxant -Mexidol.
- Subjects
THIONES; HYPERCAPNIA; PHENYLHYDRAZINE; NITROBENZENE; OXIDATION
- Publication
International Journal of Pharmaceutical Research (09752366), 2019, Vol 11, Issue 3, p1189
- ISSN
0975-2366
- Publication type
Article
- DOI
10.31838/ijpr/2019.11.03.097