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- Title
NESTIN, MARKER OF ANGIOGENESIS IN COLORECTAL CANCER.
- Authors
Jalba, C. S.; Jalba, B. A.; Ioana, M.; Cruce, M.
- Abstract
CD34 is commonly used as an endothelial cell marker of tumor vessels. However, this marker detects not only newly formed, but also pre-existing large blood vessels. Nestin, a class VI intermediate filament protein, has recently received attention as a marker for detecting newly formed endothelial cells. In this work, we have studied whether nestin is a novel angiogenesis marker in colorectal cancer. Method: Immunohistochemistry was performed with nestin and CD34 on 101 human colorectal cancer tissue samples. Results: Clinicopathological factors and prognosis were compared between two groups: that with a microvessel density (MVD) higher than the median MVD and that with MVD lower than the median MVD, as detected by nestin and CD34 labellings. The diameter of nestin-positive vessels was smaller than that of CD34-positive vessels in human colorectal cancer. There were no correlations between nestin-positive blood vessels and clinicopathological factors. Conclusion: Nestin is considered a novel angiogenesis marker of proliferating endothelial cells in colorectal cancer tissue.
- Subjects
COLON cancer; NEOVASCULARIZATION; ENDOTHELIAL seeding; HISTOCHEMISTRY; CELL proliferation; BIOMARKERS
- Publication
Annals of the Romanian Society for Cell Biology, 2009, Vol 14, Issue 1, p214
- ISSN
2067-3019
- Publication type
Article