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- Title
Assessment of Clinical and Laboratory Predictors for Chronic Childhood Immune Thrombocytopenia.
- Authors
Alpdoğan, Sedef; Gülen, Hüseyin
- Abstract
Aim: To determine the risk factors associated with chronic childhood immune thrombocytopenia (ITP). Materials and Methods: We retrospectively analyzed the medical records of 123 children with ITP who were admitted to our Department of Pediatric Hematology between May, 2006 and May, 2019. We evaluated their demographic, clinical, and laboratory characteristics, and assessed the risk factors associated with chronic ITP in childhood. Results: Of the 123 children with ITP, 60.2% were male, with an average age of 6.4±4.0 years. At follow-up, 93 (75.6%) of the patients were diagnosed as acute ITP, whereas 30 (24.4%) progressed to chronic ITP with a platelet count of lower than 100x109/L at the end of the 12-month follow-up period. Older age at admission [Odds ratio (OR): 1.4, 95% confidence interval (CI): 1.2-1.6, p<0.001], female gender (OR: 4.1, 95% CI: 1.5-10.3, p=0.003), and insidious onset of the symptoms (OR: 5.0, 95% CI: 1.1-22.6, p=0.03) were determined to be risk factors for chronic ITP. Conclusion: Our study indicates that older age, female gender and insidious onset of the disease at admission may predict chronic ITP in childhood.
- Subjects
THROMBOPENIC purpura diagnosis; CLINICAL pathology; CONFIDENCE intervals; THROMBOPENIC purpura; IMMUNE system; RETROSPECTIVE studies; RISK assessment; DESCRIPTIVE statistics; ODDS ratio; DATA analysis software; DISEASE risk factors; CHILDREN
- Publication
Journal of Pediatric Research, 2023, Vol 10, Issue 4, p278
- ISSN
2147-9445
- Publication type
Article
- DOI
10.4274/jpr.galenos.2023.06992