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- Title
Dynamics of the Antibody Response After a Third Dose of Measles-Mumps-Rubella Vaccine Indicate a Slower Decline Compared With a Second Dose.
- Authors
Kaaijk, Patricia; Nicolaie, M Alina; Rooijen, Debbie van; Houten, Marianne A van; Klis, Fiona R van der; Buisman, Anne-Marie; Binnendijk, Rob S van
- Abstract
Background Breakthrough infections of measles and mumps have raised concerns about the duration of vaccine-induced immunity, which might be improved by a third dose of measles-mumps-rubella vaccine (MMR3). Methods Here we compared (IgG) antibody levels against measles, mumps, and rubella in blood samples of 9-year-old children and young adults (18–25 years) following MMR2 and MMR3, respectively. Results We found that, in addition to antibody boosting for all 3 vaccine components, MMR3 resulted in lower antibody decay rates than MMR2; the declines were most prominent for mumps and rubella. Conclusions This study suggests that MMR3 provides long-lasting seroprotection against measles, mumps, and rubella.
- Subjects
MMR vaccines; ANTIBODY formation; RUBELLA; MUMPS; MEASLES
- Publication
Open Forum Infectious Diseases, 2020, Vol 7, Issue 11, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofaa505