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- Title
Clinical Cutaneous Features of Patients Infected With SARS-CoV-2 Hospitalized for Pneumonia: A Cross-sectional Study.
- Authors
Mascitti, Hélène; Bonsang, Benjamin; Dinh, Aurélien; Assan, Florence; Perronne, Véronique; Leblanc, Thibault; Duran, Clara; Bouchand, Frédérique; Matt, Morgan; Gal, Aurélie Le; Thanh, Julia N'guyen Van; Lanore, Aymeric; Jacob, Louis; Kiavue, Nicolas; Siméon, Soline; Bessis, Simon; Truchis, Pierre de; Landowski, Stéphanie; Davido, Benjamin; Moreau, Frédérique
- Abstract
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a current pandemic worldwide. This virus can reach all organs and disturbs the immune system, leading to a cytokine storm in severe forms. We aimed to report cutaneous features among coronavirus disease 2019 (COVID-19) hospitalized patients. Methods We performed a cross-sectional study on 1 given day among all patients hospitalized in acute care for COVID-19 and included all patients with cutaneous features. Follow-up 48 hours later was obtained. Results Among 59 adult patients hospitalized on the day of the study in an infectious diseases ward for SARS-CoV-2 infection who were confirmed by molecular assay and/or radiological findings (computed tomography scan), 40 were included. Several cutaneous manifestations were found: macular exanthema (80%), face edema (32%), livedo (13%), urticarial rash (8%), purpura (5%), oral lichenoid lesions (33%), and conjunctivitis (18%). Cutaneous biopsy was performed in 17 patients. Histological findings showed mast cell hyperplasia (100%), superficial perivascular infiltrate of lymphocytes (94%), and superficial edema (47%) consistent with capillary leak. Conclusions Various dermatological signs can be encountered during COVID-19. A macular rash was the most frequent. All cutaneous features could be related to a vascular leak process.
- Subjects
COVID-19; SARS-CoV-2; CYTOKINE release syndrome; CROSS-sectional method; CUTANEOUS manifestations of general diseases
- Publication
Open Forum Infectious Diseases, 2020, Vol 7, Issue 11, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofaa394