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- Title
HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study.
- Authors
Lindquist, Lovisa; Kilembe, William; Karita, Etienne; Price, Matt A; Kamali, Anatoli; Kaleebu, Pontiano; Tang, Jianming; Allen, Susan; Hunter, Eric; Gilmour, Jill; Rowland-Jones, Sarah L; Sanders, Eduard J; Hassan, Amin S; Esbjörnsson, Joakim
- Abstract
The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval,.01–.48]; P =.009), which warrants further studies to explore its role on HIV-1–specific immunopathogenesis.
- Subjects
HIV; SUB-Saharan Africans; IMMUNOLOGICAL deficiency syndromes; HLA histocompatibility antigens; AFRICANA studies
- Publication
Open Forum Infectious Diseases, 2024, Vol 11, Issue 4, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofae129