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- Title
Poor Outcomes of Acute Hepatitis E in Patients With Cirrhotic Liver Diseases Regardless of Etiology.
- Authors
Wang, Yijin; Liu, Hongyang; Jiang, Yiyun; Pan, Qiuwei; Zhao, Jingmin
- Abstract
Background: Chronic liver diseases (CLDs) have been documented to exacerbate clinical outcomes of acute hepatitis E (AHE). This study aimed to uncover the role of etiology and status of CLD in the adverse outcomes of AHE. We found that superinfection with hepatitis E virus (HEV) in patients with cirrhotic CLD can cause a worsen outcome, leading to exacerbation of AHE, compared with HEV-infected patients without CLD or with noncirrhotic CLD. Additional analysis revealed that the etiology of CLD is not associated with outcomes of AHE patients. These finding suggests that the overall liver status plays a predominant role in determining the outcomes of AHE.
- Subjects
HEPATITIS E; LIVER disease etiology; HEPATITIS E virus; LIVER diseases
- Publication
Open Forum Infectious Diseases, 2020, Vol 7, Issue 4, pN.PAG
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofaa107