We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lanthanum-Containing Magnesium Alloy with Antitumor Function Based on Increased Reactive Oxygen Species.
- Authors
Shuai, Cijun; Liu, Long; Yang, Youwen; Gao, Chengde; Zhao, Mingchun; Yi, Lu; Peng, Shuping
- Abstract
Developing antitumor implants is of great significance to repair tumor-induced bone defects and simultaneously prevent bone tumor recurrence. The tumor cells, compared to normal cells, have a high reactive oxygen species level. They are vulnerable to oxidative insults under increased intrinsic oxidative stress. The lanthanum (La) ion with high phospholipid binding ability can open the mitochondrial permeability transition pore, which blocks the electron transport chain in the mitochondria, and consequently increases reactive oxygen species level. In this study, La was alloyed to Mg-6Zn-0.5Zr (ZK60) through selective laser melting technology. The results indicated that the mitochondrial membrane potential dropped whilst the reactive oxygen species increased as the La content increased. ZK60-1.0La revealed a high cell inhibition rate of 61.9% for bone tumor cell and high cell viability of 91.9% for normal cells, indicating that the alloy could induce bone tumor cell death, as well as exhibit good biocompatibility for normal cell. In addition, its degradation rate 1.23 mm/year was lower than that of ZK60 alloy 2.13 mm/year, which was mainly attributed to the grain refinement.
- Subjects
MAGNESIUM alloys; ANTINEOPLASTIC agents; REACTIVE oxygen species
- Publication
Applied Sciences (2076-3417), 2018, Vol 8, Issue 11, p2109
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app8112109