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- Title
Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives.
- Authors
Wen-Xi Cai; Wei-Li Dong; Ai-Lin Liu; Zheng-Ming Li; Xing-Hai Liu; Na-Bo Sun
- Abstract
A series of novel 2-phenyl-4-trifluoromethyl thiazole-5-carboxamide derivatives have been synthesized and evaluated for their anticancer activity against A-549, Bel7402, and HCT-8 cell lines. Among the tested compounds, highest activity (48%) was achieved with the 4-chloro-2-methylphenyl amido substituted thiazole containing the 2-chlorophenyl group on the two position of the heterocyclic ring. Other structurally similar compounds displayed moderate activity. The key intermediates have been fully characterized.
- Subjects
THIAZOLE derivatives; ANTINEOPLASTIC combined chemotherapy protocols; AMIDES
- Publication
Applied Sciences (2076-3417), 2016, Vol 6, Issue 1, p8
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app6010008