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- Title
GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption.
- Authors
Watcharasit, Piyajit; Thiantanawat, Apinya; Satayavivad, Jutamaad
- Abstract
The article presents a study which investigates the involvement of glycogen synthase kinase-3 (GSK3) in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells. This has activated the executioner caspase-3 which caused cleavage of poly-ADP ribose-polymeras. In this context, the author defined arsenic as an environmental toxicant that recently has been shown to have anticancer activity against a number of types of cancer cells by inducing apoptosis. GSK3, a serine/threonine kinase, is an important pro-apoptotic signaling enzyme.
- Subjects
GLYCOGEN synthase kinase-3; APOPTOSIS; CELL death; MITOCHONDRIA; PROTEIN kinases; ORGANELLES; PROTOPLASM; MITOCHONDRIAL DNA; BACTERIOLYSIS
- Publication
Journal of Applied Toxicology, 2008, Vol 28, Issue 4, p466
- ISSN
0260-437X
- Publication type
Article
- DOI
10.1002/jat.1296