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- Title
Patient reported long‐term side effects on bowel function and anal pain in anal cancer survivors – 3‐ and 6‐year results from the Swedish national ANCA study.
- Authors
Axelsson, Anna; Johansson, Mia; Haglind, Eva; Li, Ying; Nilsson, Per J.; Angenete, Eva
- Abstract
Aim: The primary therapeutic option for anal cancer treatment is chemoradiotherapy resulting in 80% survival. The aim of this study was to assess long‐term bowel function impairment and anal pain at 3 and 6 years after anal cancer diagnosis, based on a hypothesis of an increase in impairment over time. A secondary aim was to investigate if chemoradiotherapy increased the risk for bowel impairment, compared to radiotherapy alone. Method: The ANal CAncer study (ANCA) consists of a national Swedish cohort of patients diagnosed with anal cancer between 2011–2013. Patients within the study were invited to respond to a study‐specific questionnaire at 3‐ and 6‐years after diagnosis. Descriptive analyses for the primary endpoint and ordinal logistic regressions for secondary endpoint were performed. Results: A total of 388 patients (84%) were included in the study. At 3 years of follow‐up, 264 patients were alive. A total of 195 of these patients (74%) answered a study specific questionnaire, and at 6 years 154 patients (67%). Fifty‐seven percent experienced bowel urgency at both 3 and 6 years. There was an increased risk for repeated bowel movement within 1 h (OR 2.44 [95% CI: 1.08–5.61, p = 0.03]) at 3 years in patients who had been treated by chemoradiation compared to radiotherapy alone. Conclusions: Impairment in bowel function and anal pain after anal cancer treatment should be expected and remains after 6 years. This suggests that long‐term follow‐up may be necessary in some form after customary follow‐up. The addition of chemotherapy increases long‐term side effects of bowel function.
- Subjects
ANAL cancer; CANCER pain; CANCER survivors; LOGISTIC regression analysis; CANCER treatment; CANCER diagnosis
- Publication
Colorectal Disease, 2024, Vol 26, Issue 1, p54
- ISSN
1462-8910
- Publication type
Article
- DOI
10.1111/codi.16814