We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Vaccination With Sporozoites: Models and Correlates of Protection.
- Authors
Goh, Yun Shan; McGuire, Daniel; Rénia, Laurent
- Abstract
Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines are critical to reduce mortality and morbidity. Hence, there are numerous studies investigating various malaria vaccine candidates. Most of the malaria vaccine candidates are subunit vaccines. However, they have shown limited efficacy in Phase II and III studies. To date, only whole parasite formulations have been shown to induce sterile immunity in human. In this article, we review and discuss the recent developments in vaccination with sporozoites and the mechanisms of protection involved.
- Subjects
SPOROZOITES; MALARIA vaccines; VACCINATION; VACCINES; MALARIA
- Publication
Frontiers in Immunology, 2019, pN.PAG
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2019.01227