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Animal models have little to teach us about Type 1 diabetes: 1. In support of this proposal.
Published in:
Diabetologia, 2004, v. 47, n. 10, p. 1650, doi. 10.1007/s00125-004-1517-1
By:
- Roep, B. O.;
- Atkinson, M.
Publication type:
Article
Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes I. Durinovic-Belló et al.: T helper cell reactivity to preproinsulin.
Published in:
Diabetologia, 2004, v. 47, n. 3, p. 439, doi. 10.1007/s00125-003-1315-1
By:
- Durinovic-Belló, I.;
- Schlosser, M.;
- Riedl, M.;
- Maisel, N.;
- Rosinger, S.;
- Kalbacher, H.;
- Deeg, M.;
- Ziegler, M.;
- Elliott, J.;
- Roep, B. O.;
- Karges, W.;
- Boehm, B. O.
Publication type:
Article
Distribution of HERV-LTR elements in HLA-DQB1 alleles: comments on the article by Bieda et al.
Published in:
Diabetologia, 2003, v. 46, n. 6, p. 869, doi. 10.1007/s00125-003-1113-9
By:
- Pascual, M.;
- Koeleman, B. P.;
- Eerligh, P.;
- Roep, B. O.;
- Martin, J.
Publication type:
Article
Modulation of autoimmunity to beta-cell antigens by proteases B. O. Roep et al.: Modulation of autoimmunity by proteases.
Published in:
Diabetologia, 2002, v. 45, n. 5, p. 686, doi. 10.1007/s00125-002-0797-6
By:
- Roep, B. O.;
- van den Engel, N. K.;
- van Halteren, A. G. S.;
- Duinkerken, G.;
- Martin, S.
Publication type:
Article
Failure and Success in Abolition of Virus-Specific CTL-Response Defects by Dendritic Cells.
Published in:
Annals of the New York Academy of Sciences, 1988, v. 532, n. 1, p. 413, doi. 10.1111/j.1749-6632.1988.tb36359.x
By:
- KAST, W. M.;
- BOOG, C. J. P.;
- ROEP, B. O.;
- VOORDOUW, A. C.;
- MELIEF, C. J. M.
Publication type:
Article
Post-transcriptional control of candidate risk genes for type 1 diabetes by rare genetic variants.
Published in:
Genes & Immunity, 2013, v. 14, n. 1, p. 58, doi. 10.1038/gene.2012.38
By:
- de Jong, V M;
- Zaldumbide, A;
- van der Slik, A R;
- Persengiev, S P;
- Roep, B O;
- Koeleman, B P C
Publication type:
Article
Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes.
Published in:
Genes & Immunity, 2011, v. 12, n. 6, p. 415, doi. 10.1038/gene.2011.24
By:
- Eerligh, P;
- van Lummel, M;
- Zaldumbide, A;
- Moustakas, A K;
- Duinkerken, G;
- Bondinas, G;
- Koeleman, B P C;
- Papadopoulos, G K;
- Roep, B O
Publication type:
Article
Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes.
Published in:
Genes & Immunity, 2006, v. 7, n. 7, p. 544, doi. 10.1038/sj.gene.6364326
By:
- Zhernakova, A.;
- Alizadeh, B. Z.;
- Eerligh, P.;
- Hanifi-Moghaddam, P.;
- Schloot, N. C.;
- Diosdado, B.;
- Wijmenga, C.;
- Roep, B. O.;
- Koeleman, B. P. C.
Publication type:
Article
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.
Published in:
Genes & Immunity, 2005, v. 6, n. 6, p. 459, doi. 10.1038/sj.gene.6364220
By:
- Zhernakova, A.;
- Eerligh, P.;
- Wijmenga, C.;
- Barrera, P.;
- Roep, B. O.;
- Koeleman, B. P. C.
Publication type:
Article
Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease.
Published in:
Genes & Immunity, 2004, v. 5, n. 5, p. 381, doi. 10.1038/sj.gene.6364106
By:
- Koeleman, B. P. C.;
- Lie, B. A.;
- Undlien, D. E.;
- Dudbridge, F.;
- Thorsby, E.;
- de Vries, R. R. P.;
- Cucca, F.;
- Roep, B. O.;
- Giphart, M. J.;
- Todd, J. A.
Publication type:
Article
Persistent C‐peptide is associated with reduced hypoglycaemia but not HbA1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?
Published in:
Diabetic Medicine, 2019, v. 36, n. 9, p. 1092, doi. 10.1111/dme.13960
By:
- Marren, S. M.;
- Hammersley, S.;
- McDonald, T. J.;
- Shields, B. M.;
- Knight, B. A.;
- Hill, A.;
- Bolt, R.;
- Tree, T. I.;
- Roep, B. O.;
- Hattersley, A. T.;
- Jones, A. G.;
- Oram, R. A.
Publication type:
Article
Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes.
Published in:
2012
By:
- Kaas, A.;
- Pfleger, C.;
- Kharagjitsingh, A. V.;
- Schloot, N. C.;
- Hansen, L.;
- Buschard, K.;
- Koeleman, B. P. C.;
- Roep, B. O.;
- Mortensen, H. B.;
- Alizadeh, B. Z.
Publication type:
Journal Article
Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes.
Published in:
Diabetic Medicine, 2012, v. 29, n. 6, p. 734, doi. 10.1111/j.1464-5491.2011.03544.x
By:
- Kaas, A.;
- Pfleger, C.;
- Kharagjitsingh, A. V.;
- Schloot, N. C.;
- Hansen, L.;
- Buschard, K.;
- Koeleman, B. P. C.;
- Roep, B. O.;
- Mortensen, H. B.;
- Alizadeh, B. Z.
Publication type:
Article
Reduced frequency of blood group Lewis a−b− in female Type 1 diabetes patients.
Published in:
Diabetic Medicine, 2008, v. 25, n. 2, p. 236, doi. 10.1111/j.1464-5491.2007.02340.x
By:
- Kharagjitsingh, A. V.;
- Prinsen, K.;
- Lemkes, H. H. P. J.;
- de Vries, R. R. P.;
- Roep, B. O.;
- Buschard, K.
Publication type:
Article
Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission.
Published in:
Diabetic Medicine, 2007, v. 24, n. 5, p. 512, doi. 10.1111/j.1464-5491.2007.02096.x
By:
- Schloot, N. C.;
- Hanifi-Moghaddam, P.;
- Aabenhus-Andersen, N.;
- Alizadeh, B. Z.;
- Saha, M. T.;
- Knip, M.;
- Devendra, D.;
- Wilkin, T.;
- Bonifacio, E.;
- Roep, B. O.;
- Kolb, H.;
- Mandrup-Poulsen, T.
Publication type:
Article
Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus.
Published in:
Diabetic Medicine, 2006, v. 23, n. 2, p. 156, doi. 10.1111/j.1464-5491.2005.01743.x
By:
- Hanifi-Moghaddam, P.;
- Kappler, S.;
- Seissler, J.;
- Müller-Scholze, S.;
- Martin, S.;
- Roep, B. O.;
- Strassburger, K.;
- Kolb, H.;
- Schloot, N. C.
Publication type:
Article
Molecular Mimicry in Type 1 Diabetes.
Published in:
Annals of the New York Academy of Sciences, 2002, v. 958, n. 1, p. 163, doi. 10.1111/j.1749-6632.2002.tb02961.x
By:
- ROEP, B. O.;
- HIEMSTRA, H. S.;
- SCHLOOT, N. C.;
- VRIES, R. R. P.;
- CHAUDHURI, A.;
- BEHAN, P. O.;
- DRIJFHOUT, J. W.
Publication type:
Article
HLA-DQ polymorphism and degree of heteroplasmy of the A3243G mitochondrial DNA mutation in maternally inherited diabetes and deafness.
Published in:
Diabetic Medicine, 2000, v. 17, n. 12, p. 841, doi. 10.1046/j.1464-5491.2000.00379.x
By:
- van Essen, E. H. R.;
- Roep, B. O.;
- Hart, L. M. ′t;
- Jansen, J. J.;
- Van den Ouweland, J. M. W.;
- Lemkes, H. H. P. J.;
- Maassen, J. A.
Publication type:
Article
Selective unresponsiveness to beta cell autoantigens after induction immunosuppression in pancreas transplantation with anti-interleukin-2 receptor antibody versus anti-thymocyte globulin.
Published in:
Clinical & Experimental Immunology, 2007, v. 149, n. 1, p. 56, doi. 10.1111/j.1365-2249.2007.03400.x
By:
- van de Linde, P.;
- Boog, P. J. M. vd;
- Tysma, O. M. H.;
- Elliott, J. F.;
- Roelen, D. L.;
- Claas, F. H. J.;
- de Fijter, J. W.;
- Roep, B. O.
Publication type:
Article
Translational Mini-Review Series on Type 1 Diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.
Published in:
Clinical & Experimental Immunology, 2007, v. 148, n. 1, p. 1, doi. 10.1111/j.1365-2249.2006.03244.x
By:
- Di Lorenzo, T. P.;
- Peakman, M.;
- Roep, B. O.
Publication type:
Article
Association of interferon-γ and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes.
Published in:
Clinical & Experimental Immunology, 2006, v. 145, n. 3, p. 480, doi. 10.1111/j.1365-2249.2006.03172.x
By:
- Alizadeh, B. Z.;
- Hanifi-Moghaddam, P.;
- Eerligh, P.;
- van der Slik, A. R.;
- Kolb, H.;
- Kharagjitsingh, A. V.;
- Arias, A. M. Pereira;
- Ronkainen, M.;
- Knip, M.;
- Bonfanti, R.;
- Bonifacio, E.;
- Devendra, D.;
- Wilkin, T.;
- Giphart, M. J.;
- Koeleman, B. P. C.;
- Nolsøe, R.;
- Poulsen, T. Mandrup;
- Schloot, N. C.;
- Roep, B. O.
Publication type:
Article
Human islets and dendritic cells generate post-translationally modified islet autoantigens.
Published in:
Clinical & Experimental Immunology, 2016, v. 185, n. 2, p. 133, doi. 10.1111/cei.12775
By:
- McLaughlin, R. J.;
- de Haan, A.;
- Zaldumbide, A.;
- de Koning, E. J.;
- de Ru, A. H.;
- van Veelen, P. A.;
- van Lummel, M.;
- Roep, B. O.
Publication type:
Article
Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model.
Published in:
Clinical & Experimental Immunology, 2015, v. 182, n. 3, p. 251, doi. 10.1111/cei.12687
By:
- Gibson, V. B.;
- Nikolic, T.;
- Pearce, V. Q.;
- Demengeot, J.;
- Roep, B. O.;
- Peakman, M.
Publication type:
Article
Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
Published in:
Clinical & Experimental Immunology, 2015, v. 179, n. 3, p. 398, doi. 10.1111/cei.12465
By:
- Babad, J.;
- Mukherjee, G.;
- Follenzi, A.;
- Ali, R.;
- Roep, B. O.;
- Shultz, L. D.;
- Santamaria, P.;
- Yang, O. O.;
- Goldstein, H.;
- Greiner, D. L.;
- DiLorenzo, T. P.
Publication type:
Article
CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity.
Published in:
Clinical & Experimental Immunology, 2012, v. 170, n. 1, p. 57, doi. 10.1111/j.1365-2249.2012.04635.x
By:
- Abreu, J. R. F.;
- Martina, S.;
- Verrijn Stuart, A. A.;
- Fillié, Y. E.;
- Franken, K. L. M. C.;
- Drijfhout, J. W.;
- Roep, B. O.
Publication type:
Article
Immune responses against islet allografts during tapering of immunosuppression - a pilot study in 5 subjects.
Published in:
Clinical & Experimental Immunology, 2012, v. 169, n. 2, p. 190, doi. 10.1111/j.1365-2249.2012.04605.x
By:
- Huurman, V. A. L.;
- van der Torren, C. R.;
- Gillard, P.;
- Hilbrands, R.;
- van der Meer-Prins, E. P. M. W.;
- Duinkerken, G.;
- Gorus, F. K.;
- Claas, F. H. J.;
- Keymeulen, B.;
- Roelen, D. L.;
- Pipeleers, D. G.;
- Roep, B. O.
Publication type:
Article
Association of adiponectin, interleukin (IL)-1ra, inducible protein 10, IL-6 and number of islet autoantibodies with progression patterns of type 1 diabetes the first year after diagnosis.
Published in:
Clinical & Experimental Immunology, 2010, v. 161, n. 3, p. 444, doi. 10.1111/j.1365-2249.2010.04193.x
By:
- Kaas, A.;
- Pfleger, C.;
- Hansen, L.;
- Buschard, K.;
- Schloot, N. C.;
- Roep, B. O.;
- Mortensen, H. B.
Publication type:
Article
Islet inflammation and CXCL10 in recent-onset type 1 diabetes.
Published in:
Clinical & Experimental Immunology, 2010, v. 159, n. 3, p. 338, doi. 10.1111/j.1365-2249.2009.04087.x
By:
- Roep, B. O.;
- Kleijwegt, F. S.;
- van Halteren, A. G. S.;
- Bonato, V.;
- Boggi, U.;
- Vendrame, F.;
- Marchetti, P.;
- Dotta, F.
Publication type:
Article
Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation.
Published in:
Clinical & Experimental Immunology, 2009, v. 156, n. 1, p. 141, doi. 10.1111/j.1365-2249.2008.03812.x
By:
- Roelen, D. L.;
- Huurman, V. A. L.;
- Hilbrands, R.;
- Gillard, P.;
- Duinkerken, G.;
- van der Meer-Prins, P. W. M.;
- Maarschalk, M. F. J. Versteeg-van der Voort;
- Mathieu, C.;
- Keymeulen, B.;
- Pipeleers, D. G.;
- Roep, B. O.;
- Claas, F. H. J.
Publication type:
Article
Immunological efficacy of heat shock protein 60 peptide DiaPep277TM therapy in clinical type I diabetes.
Published in:
Clinical & Experimental Immunology, 2008, v. 152, n. 3, p. 488, doi. 10.1111/j.1365-2249.2008.03656.x
By:
- Huurman, V. A. L.;
- van der Meide, P. E.;
- Duinkerken, G.;
- Willemen, S.;
- Cohen, I. R.;
- Elias, D.;
- Roep, B. O.
Publication type:
Article
Differential inhibition of autoreactive memory- and alloreactive naive T cell responses by soluble cytotoxic T lymphocyte antigen 4 (sCTLA4), CTLA4Ig and LEA29Y.
Published in:
Clinical & Experimental Immunology, 2007, v. 150, n. 3, p. 487, doi. 10.1111/j.1365-2249.2007.03513.x
By:
- Huurman, V. A. L.;
- Unger, W. W. J.;
- Koeleman, B. P. C.;
- Oaks, M. K.;
- Chandraker, A. K.;
- Terpstra, O. T.;
- Roep, B. O.
Publication type:
Article
Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes.
Published in:
2001
By:
- Peakman, Mark;
- Tree, Timothy I.;
- Endl, Josef;
- Van Endert, Peter;
- Atkinson, Mark A.;
- Roep, Bart O.;
- Peakman, M;
- Tree, T I;
- Endl, J;
- van Endert, P;
- Atkinson, M A;
- Roep, B O;
- Second International Immunology of Diabetes Society Workshop for Standardization ot T-cell Assays in Type 1 Diabetes
Publication type:
journal article
T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.
Published in:
2000
By:
- Hawkes, Charlotte J.;
- Schloot, Nanette C.;
- Marks, Joanne;
- Willemen, Sabine J.M.;
- Drijfhout, Jan W.;
- Mayer, Erik K.;
- Christie, Michael R.;
- Roep, Bart O.;
- Hawkes, C J;
- Schloot, N C;
- Marks, J;
- Willemen, S J;
- Drijfhout, J W;
- Mayer, E K;
- Christie, M R;
- Roep, B O
Publication type:
journal article
Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.
Published in:
1999
By:
- Roep, Bart O.;
- Stobbe, Inge;
- Duinkerken, Gaby;
- van Rood, Jon J.;
- Lernmark, Ake;
- Keymeulen, Bart;
- Pipeleers, Danny;
- Claas, Frans H.J.;
- de Vries, Rene R.P.;
- Roep, B O;
- Stobbe, I;
- Duinkerken, G;
- van Rood, J J;
- Lernmark, A;
- Keymeulen, B;
- Pipeleers, D;
- Claas, F H;
- de Vries, R R
Publication type:
journal article
HLA-DR binding analysis of peptides from islet antigens in IDDM.
Published in:
1998
By:
- Geluk, Annemieke;
- van Meijgaarden, Krista E.;
- Schloot, Nanette C.;
- Drijfhout, Jan Wouter;
- Ottenhoff, Tom H.M.;
- Roep, Bart O.;
- Geluk, A;
- van Meijgaarden, K E;
- Schloot, N C;
- Drijfhout, J W;
- Ottenhoff, T H;
- Roep, B O
Publication type:
journal article
TNFa microsatellite polymorphism modulates the risk of IDDM in Caucasians with the high-risk genotype HLA DQA1*0501-DQB1*0201/DQA1*0301-DQB1*0302. Belgian Diabetes Registry.
Published in:
1997
By:
- Moghaddam, Payman Hanifi;
- Zwinderman, Aeilko H.;
- de Knijff, Peter;
- Roep, Bart O.;
- Schipper, Ron F.;
- Van Der Auwera, Bart;
- Naipal, Albert;
- Gorus, Frans;
- Schuit, Frans;
- Giphart, Marius J.;
- Moghaddam, P H;
- Zwinderman, A H;
- de Knijff, P;
- Roep, B O;
- Schipper, R F;
- Van der Auwera, B;
- Naipal, A;
- Gorus, F;
- Schuit, F;
- Giphart, M J
Publication type:
journal article
T-cell responses to autoantigens in IDDM. The search for the Holy Grail.
Published in:
1996
By:
- Roep, B O
Publication type:
journal article
T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM.
Published in:
1995
By:
- Roep, B O;
- Kallan, A A;
- Duinkerken, G;
- Arden, S D;
- Hutton, J C;
- Bruining, G J;
- de Vries, R R
Publication type:
journal article
Beta-cell antigen-specific lysis of macrophages by CD4 T-cell clones from newly diagnosed IDDM patient. A putative mechanism of T-cell-mediated autoimmune islet cell destruction.
Published in:
1992
By:
- Roep, B O;
- Kallan, A A;
- De Vries, R R
Publication type:
journal article
T-lymphocytes and the pathogenesis of type 1 (insulin-dependent) diabetes mellitus.
Published in:
European Journal of Clinical Investigation, 1992, v. 22, n. 11, p. 697, doi. 10.1111/j.1365-2362.1992.tb01433.x
By:
- ROEP, B. O.;
- VRIES, R. R. P. DE
Publication type:
Article
Multifocal or generalized tonic dystonia of complex regional pain syndrome: a distinct clinical entity associated with HLA-DR13.
Published in:
2000
By:
- Van Hilten, J. J.;
- Van De Beek, W. J. T.;
- Roep, B. O.;
- van de Beek, W J
Publication type:
journal article
Revisiting infant growth prior to childhood onset type 1 diabetes.
Published in:
Clinical Endocrinology, 2010, v. 72, n. 5, p. 620, doi. 10.1111/j.1365-2265.2009.03691.x
By:
- Kharagjitsingh, A. V.;
- de Ridder, M. A. J.;
- Roep, B. O.;
- Koeleman, B. P. C.;
- Bruining, G. J.;
- Veeze, H. J.
Publication type:
Article

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