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- Title
Centromere-associated meiotic drive and female fitness variation in Mimulus.
- Authors
Fishman, Lila; Kelly, John K.
- Abstract
Female meiotic drive, in which chromosomal variants preferentially segregate to the egg pole during asymmetric female meiosis, is a theoretically pervasive but still mysterious form of selfish evolution. Like other selfish genetic elements, driving chromosomes may be maintained as balanced polymorphisms by pleiotropic or linked fitness costs. A centromere-associated driver ( D) with a ∼58:42 female-specific transmission advantage occurs at intermediate frequency (32-40%) in the Iron Mountain population of the yellow monkeyflower, Mimulus guttatus. Previously determined male fertility costs are sufficient to prevent the fixation of D, but predict a higher equilibrium frequency. To better understand the dynamics and effects of D, we developed a new population genetic model and measured genotype-specific lifetime female fitness in the wild. In three of four years, and across all years, D imposed significant recessive seedset costs, most likely due to hitchhiking by deleterious mutations. With both male and female costs as measured, and 58:42 drive, our model predicts an equilibrium frequency of D (38%) very close to the observed value. Thus, D represents a rare selfish genetic element whose local population genetic dynamics have been fully parameterized, and the observation of equilibrium sets the stage for investigations of coevolution with suppressors.
- Subjects
MONKEYFLOWERS; PLANT centromere; MEIOSIS; SELFISH genetic elements; MEIOTIC drive; PLANT evolution; PLANT population genetics; PLANT mutation; PLANTS
- Publication
Evolution, 2015, Vol 69, Issue 5, p1208
- ISSN
0014-3820
- Publication type
Article
- DOI
10.1111/evo.12661