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- Title
Multifunctional ZnO@DOX/ICG-LMHP Nanoparticles for Synergistic Multimodal Antitumor Activity.
- Authors
Li, Zhuoyue; Wang, Jingru; Liu, Junwei; Yu, Jianming; Wang, Jingwen; Wang, Hui; Wei, Qingchao; Liu, Man; Xu, Meiqi; Feng, Zhenhan; Zhong, Ting; Zhang, Xuan
- Abstract
Multifunctional nanoparticles are of significant importance for synergistic multimodal antitumor activity. Herein, zinc oxide (ZnO) was used as pH-sensitive nanoparticles for loading the chemotherapy agent doxorubicin (DOX) and the photosensitizer agent indocyanine green (ICG), and biocompatible low-molecular-weight heparin (LMHP) was used as the gatekeepers for synergistic photothermal therapy/photodynamic therapy/chemotherapy/immunotherapy. ZnO was decomposed into cytotoxic Zn2+ ions, leading to a tumor-specific release of ICG and DOX. ZnO simultaneously produced oxygen (O2) and reactive oxygen species (ROS) for photodynamic therapy (PDT). The released ICG under laser irradiation produced ROS for PDT and raised the tumor temperature for photothermal therapy (PTT). The released DOX directly caused tumor cell death for chemotherapy. Both DOX and ICG also induced immunogenic cell death (ICD) for immunotherapy. The in vivo and in vitro results presented a superior inhibition of tumor progression, metastasis and recurrence. Therefore, this study could provide an efficient approach for designing multifunctional nanoparticles for synergistic multimodal antitumor therapy.
- Subjects
PHOTOTHERMAL effect; ANTINEOPLASTIC agents; DOXORUBICIN; LOW-molecular-weight heparin; REACTIVE oxygen species; ZINC oxide; INDOCYANINE green; PHOTODYNAMIC therapy
- Publication
Journal of Functional Biomaterials, 2024, Vol 15, Issue 2, p35
- ISSN
2079-4983
- Publication type
Article
- DOI
10.3390/jfb15020035