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- Title
A Nondilated Main Pancreatic Duct Predicts Type 2 Autoimmune Pancreatitis: Comparative Study of Resected Pancreatic Head Masses.
- Authors
Peláez-Luna, Mario; Medina-Campos, Claudia; Uscanga-Domínuez, Luis; Hernandez-Calleros, Jorge; Chan-Nuñez, Carlos; Negrete, Eduardo; Angeles, Arturo
- Abstract
Background: Chronic pancreatitis (CP), pancreatic cancer (PCa), and autoimmune pancreatitis (AIP) often present as a pancreatic mass. Accurate diagnosis is not always possible; up to 8% of surgical procedures are performed in benign pancreatic masses presumed to be malignant. Objectives: We aimed to compare clinical and imaging characteristics of resected focal type 2 AIP, CP, and PCa and identify factors that could improve preoperative differential diagnosis. Methods: Charts from patients that underwent pancreatic resection under suspicion of PCa between 2000 and 2014 were reviewed. Clinical and imaging data were recorded. Subjects were grouped as type 2 AIP, CP, and PCa. Results: We included 79 cases; 41 men, mean age of 57.3 years/old ± 15.6 SD. Pathology report was type 2 AIP (20%), CP (10%), and PCa (70%). According to international consensus criteria for AIP 11 cases were deemed probable type 2 and 5 as unspecific pancreatic mass. A nondilated main pancreatic duct (MPD) was associated with AIP (OR 9.3; 95% CI 3.05–28.7), p < 0.001; obstructive jaundice (OR 28.5; 95% CI 8.18–79.5); and a dilated MPD (OR 5.21; 95% CI 1.9–14.6) suggested malignancy. Conclusions: In the setting of undetermined pancreatic focal mass, a nondilated MPD suggests the diagnosis of type 2 AIP.
- Subjects
PANCREATIC duct; PANCREATITIS; CHRONIC pancreatitis; PANCREATIC cancer; DIAGNOSTIC imaging; OBSTRUCTIVE jaundice
- Publication
Digestion, 2020, Vol 101, Issue 2, p137
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000497140