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- Title
Incidence, Clinical Characteristics, Long-Term Course, and Comparison of Progressive and Nonprogressive Cases of Aphthous-Type Crohn's Disease: A Single-Center Cohort Study.
- Authors
Tsurumi, Kozue; Matsui, Toshiyuki; Hirai, Fumihito; Takatsu, Noritaka; Yano, Yutaka; Hisabe, Takashi; Sato, Yuho; Beppu, Takahiro; Fujiwara, Shoko; Ishikawa, Satoshi; Matsushima, Yu; Okado, Yuki; Ono, Yoichiro; Yoshizawa, Naoyuki; Nagahama, Takashi; Takaki, Yasuhiro; Yao, Kenshi; Iwashita, akinori
- Abstract
Background/Aims: In Japan, aphthous-type Crohn's disease (type A CD) is thought to represent an early phase of Crohn's disease (CD), and diagnosis of type A CD is possible in the diagnostic criteria for CD in Japan. However, the details of type A CD are not well understood. Methods: Subjects comprised 649 CD patients diagnosed between 1985 and 2011. The incidence of type A CD over time was clarified in two periods (1985-2004 and 2005-2011). The course of type A CD was also investigated, and cases that did and did not progress to typical CD were compared. Results: No significant difference was seen in the incidence of type A CD between the two periods (5.2 vs. 8.5%, p = 0.125). Type A CD patients followed at our hospital progressed to typical CD at a rate of 59.3%. In comparing progressive and nonprogressive cases, the frequency of large, densely distributed aphthous lesions in the small intestine was higher among progressive cases (p = 0.018). Conclusion: Type A CD is an early phase of CD, and CD diagnostic criteria including early cases are valid in Japan. Copyright © 2013 S. Karger AG, Basel
- Subjects
CROHN'S disease diagnosis; DISEASE progression; CANKER sores; SMALL intestine ulcers; DIAGNOSIS
- Publication
Digestion, 2013, Vol 87, Issue 4, p262
- ISSN
0012-2823
- Publication type
Article
- DOI
10.1159/000350615