Allergic or hypersensitivity reactions with chest pain occurs at the same time brings to mind Konis Syndrome. this event described as and allergic angina syndrome by Kounis and Zavras in 1991.Our case is about lansoprazole Induced Kounis Syndrome. Lansoprazole is a proton pump inhibitor taken for reducing gastric acid secretion. Adverse effects of lansoprozole are nausea and vomiting. Kounis yndrome has been reported rarely.