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- Title
The use of botulinum toxin- A in the management of neck and anterior chest wall flushing: pilot study.
- Authors
Geddoa, Emad; Matar, Hosam E; Paes, Trevor Rudrah Franco
- Abstract
Idiopathic neck and chest wall flushing could cause disabling effects on patients' quality of life. We aimed to evaluate the effectiveness of botulinum toxin-A ( BTA) in the management of idiopathic neck and chest wall flushing. This was a pilot prospective clinical study of patients with severe idiopathic neck and anterior chest wall flushing. Two mouse units of BTA were injected intracutaneously with a maximum dose of 100 units per patient per session. The dermatology life quality index is used as the primary outcome measure. Twenty-two patients were included in the study (18 women, four men) with an average age of 26 years (range 18-48). Twenty patients (90.9%) had immediate improvement with almost complete resolution of their flushing. At four weeks follow-up, 18 of 22 patients were included in the final analysis, significant improvement in quality of life was achieved, and mean baseline dermatology life quality index score 7.78 ( SD 3.25) improved significantly to 4.23 ( SD 3.44) with a mean difference of 3.56 ( SD 4.6; 95%, confidence interval 1.27, 5.84) with paired samples t-test 3.29 (d.f. 17) P < 0.004. BTA may provide an effective treatment in the management of idiopathic neck and chest wall flushing.
- Subjects
BOTULINUM toxin; THERAPEUTICS; BLUSHING; QUALITY of life; DERMATOLOGY; ROSACEA; MANAGEMENT
- Publication
International Journal of Dermatology, 2013, Vol 52, Issue 12, p1547
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.12200