We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps.
- Authors
Rajão^Gomes, Monete; Guimarães, Ana Carolina Ramos; de Miranda, Antonio Basílio
- Abstract
Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryps) are unicellular protozoa that cause leishmaniasis, sleeping sickness and Chagas' disease, respectively. Most drugs against them were discovered through the screening of large numbers of compounds against whole parasites. Nonhomologous isofunctional enzymes (NISEs) may present good opportunities for the identification of new putative drug targets because, though sharing the same enzymatic activity, they possess different three-dimensional structures thus allowing the development of molecules against one or other isoform. Frompublic data of the Tritryps' genomes, we reconstructed the Genetic Information Processing Pathways (GIPPs). We then used AnEnPi to look for the presence of these enzymes between Homo sapiens and Tritryps, as well as specific enzymes of the parasites. We identified three candidates (ECs 3.1.11.2 and 6.1.1.-) in these pathways that may be further studied as new therapeutic targets for drug development against these parasites.
- Subjects
ENZYMES; LEISHMANIA; TRYPANOSOMA brucei; TRYPANOSOMA cruzi; DRUG development; GENOMICS
- Publication
Enzyme Research, 2011, p1
- ISSN
2090-0406
- Publication type
Article
- DOI
10.4061/2011/543912