We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Endocrine mucin-producing sweat gland carcinoma: A case report.
- Authors
Sidiropoulos, Konstantinos Gus; Wolff, Alan; Sidiropoulos, Michael
- Abstract
Endocrine mucin-producing sweat gland carcinomas (EMPSGC) are rare cutaneous adnexal tumours with a predilection to the eyelid. A key differential diagnosis is excluding a metastasis from a breast carcinoma, as EMPSGC is similar to low-grade/borderline breast carcinomas referred to as solid papillary carcinoma, both demonstrating similar cytologic characteristics and endocrine features. Here, we describe an additional case of EMPSGC presenting on the right lateral canthus of a 67-year-old female. Clinically, the tumour presented as a slow growing swelling. Histology the lesion demonstrated a wellcircumscribed multi-nodular tumour, with solid and cystic nodules. Also identified was a papillary architecture, multiple lumina, and the presence of mucin. No connection to the epidermis was identified. Tumour cells were small to medium-sized oval to polygonal epithelial cells with bland nuclei and inconspicuous nucleoli and pale to pink cytoplasm. Apical snouts consistent with apocrine differentiation were also focally noted. Rare mitotic activity was identified. Immunohistochemical analysis showed that tumour cells of the surface epithelium were positive for cytokeratin (CK) 7, CEA, EMA, synaptophysin, estrogen receptor and progesterone receptor and negative for CK20. Immunohistochemical staining with p63 demonstrated myoepithelial cells partially lining tumour nodules. A Ki67 showed moderate proliferative activity within the lesion. Although there is limited data available, the current literature supports that EMPSGC has a good prognosis with documented local recurrences, but no known metastases reported to date.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p33
- ISSN
1918-915X
- Publication type
Article