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- Title
Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion.
- Authors
Kuan-Yuan Chen; Po-Hao Feng; Chih-Cheng Chang; Tzu-Tao Chen; Hsiao-Chi Chuang; Chun-Nin Lee; Chien-Ling Su; Lian-Yu Lin; Kang-Yun Lee
- Abstract
Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1β and interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P<0.05 and P<0.01, respectively). Of the adaptive immunity biomarkers, the median levels of IL-13 and interferon-γ (IFN-γ) were higher in TPE patients than in MPE patients (P<0.05). In addition, the levels of basic fibroblast growth factor were higher in MPE patients than in TPE patients (P<0.05). Receiver operator characteristic analysis of these biomarkers was performed, resulting in the highest area under the curve (AUC) for IP-10 (AUC =0.95, 95% confidence interval, P<0.01), followed by IL-13 (AUC =0.86, 95% confidence interval, P<0.05). Our study shows that five biomarkers (IL-1β, IP-10, IFN-γ, IL-13, and basic fibroblast growth factor) have a potential diagnostic role in differentiating TPE from MPE, particularly in lung cancer-related MPE.
- Subjects
PLEURAL effusions; TUBERCULOSIS; BIOMARKERS; PLEURISY; IMMUNE response; INTERLEUKINS; CELL differentiation
- Publication
International Journal of General Medicine, 2016, Vol 9, p183
- ISSN
1178-7074
- Publication type
Article
- DOI
10.2147/IJGM.S100237