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- Title
SPIN LABELLED HEMOGLOBIN-BASED OXYGEN CARRIERS (HBOC): PREPARATION AND EVALUATION OF IN VIVO / IN VITRO STABILITY.
- Authors
SILAGHI-DUMITRESCU, RADU; GRUIAN, CRISTINA; PUSCAS, CRISTINA; SIMON, ALEXANDRA; FISHER-FODOR, EVA; TOMA, VLAD AL.; FARCAS, ANCA; ROMAN, IOANA; SCURTU, VIOLETA-FLORINA; ATTIA, AMR A. A.; DAMIAN, GRIGORE
- Abstract
Site-directed spin labeling and EPR characterization (continuous wave as well as DEER) of two blood substitute candidates is described for the first time: glutaraldehyde-polymerized bovine hemoglobin and the related hemoglobin-albumin copolymer. In vitro, with two different types of cell cultures, these spin-labeled candidates are relatively stable; however, they appear to be rapidly reduced in vivo, most likely via removal or reduction of the spin label (as opposed to removal of the blood substitute candidate from the circulatory system altogether).
- Subjects
BLOOD substitutes; CARDIOVASCULAR system; SPIN labels; OXYGEN carriers; CELL culture
- Publication
Studia Universitatis Babes-Bolyai, Chemia, 2020, Vol 65, Issue 2, p121
- ISSN
1224-7154
- Publication type
Article
- DOI
10.24193/subbchem.2020.2.10