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- Title
Programmable enantioselective one-pot synthesis of molecules with eight stereocenters.
- Authors
Potowski, Marco; Schürmann, Markus; Preut, Hans; Antonchick, Andrey P; Waldmann, Herbert
- Abstract
We developed an enantioselectively catalyzed tandem synthesis of structurally and stereochemically complex molecules that forms four carbon-carbon bonds and sets eight stereocenters with high regio-, diastereo- and enantioselectivity. It can be programmed to yield different stereoisomers by varying only the order of combination of a common set of reagents and catalysts. We report what is to our knowledge the first synthesis of both enantiomers of a chiral compound using the same chiral catalyst.
- Subjects
ENANTIOSELECTIVE catalysis; STEREOCHEMISTRY; CARBON-carbon bonds synthesis; STEREOISOMERS; CHEMICAL reagents
- Publication
Nature Chemical Biology, 2012, Vol 8, Issue 5, p428
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.901