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- Title
Epidemiology of Drug-resistant Tuberculosis in a Tertiary Care Center in Oman, 2006-2015.
- Authors
Gaifer, Zied; Rizavi, Dawar; Babiker, Ahmed
- Abstract
Objectives: The aim of this study was to estimate the prevalence and identify the risk factors for the development of drug-resistant Mycobacterium tuberculosis infection in a tertiary care center in Oman. Methods: We performed a cross-sectional review of culture-confirmed tuberculosis (TB) cases diagnosed at Sultan Qaboos University Hospital between August 2006 and March 2015. We compared drug-resistant TB cases with drug-sensitive cases to identify predictors of drug-resistant TB using univariate and multivariate logistic regression analysis. Results: Of the 260 TB cases reviewed, 73.1% were confirmed by culture. The proportion of multi-drug resistant TB was 1.8%. TB isolates resistant to any of the first-line TB drugs comprised (7.5%) of cases. Pyrazinamide monoresistance was the most frequently reported drug monoresistant pattern (3.5%). Previous treatment for TB (odds ratio (OR) 14.81; 95% CI 3.09-70.98, p < 0.001), female gender (OR 3.85; 95% Cl 1.07-13.90, p < 0.039), and younger age (OR 6.80; 95% Cl 1.61-28.75, p < 0.009) were found to be risk factors for development of first-line antituberculosis drug-resistant TB in multivariate analysis. Conclusions: Our results show that the rate of drug-resistant TB in our population is a public health issue of great concern. Previous treatment with antituberculosis drugs, female gender, and younger age are risk factors for the development of drug-resistant TB. These findings are useful adjuvants to guide clinicians and public health professionals in the early detection and appropriate treatment of cases of drug-resistant TB.
- Subjects
OMAN; TUBERCULOSIS risk factors; TUBERCULOSIS epidemiology; ACADEMIC medical centers; AGE distribution; COMPARATIVE studies; CONFIDENCE intervals; DRUG resistance in microorganisms; MULTIVARIATE analysis; MYCOBACTERIUM tuberculosis; PROBABILITY theory; PUBLIC health; SEX distribution; STATISTICS; LOGISTIC regression analysis; DISEASE prevalence; CROSS-sectional method; DESCRIPTIVE statistics; ODDS ratio
- Publication
Oman Medical Journal, 2017, Vol 32, Issue 1, p36
- ISSN
1999-768X
- Publication type
Article
- DOI
10.5001/omj.2017.07