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- Title
Functions and mechanism of noncoding RNA in the somatic cells of the testis.
- Authors
Li, Chunjie; Chen, Baiqi; Wang, Jing
- Abstract
Summary: ncRNAs are involved in numerous biological processes by regulating gene expression and cell stability. Studies have shown that ncRNAs also contribute to spermatogenesis. Leydig cells (LCs) and Sertoli cells (SCs) are somatic cells of the testis that support spermatogenesis and are vital to male fertility. In this review, we summarized the findings from studies on ncRNAs in SCs and LCs. In SCs, ncRNAs play key roles in phagocytosis, immunoprotection and development of SCs. In LCs, ncRNAs are involved in steroidogenesis, in particular production of testosterone as well as development of LCs. Here, we discuss the possible target genes and functions of ncRNAs in both types of cells. These ncRNAs regulate the expression of target genes or mRNA coding sequence regions, resulting in a chain reaction that influences cell function. In addition, microRNAs, lncRNAs, piRNA-like RNAs (pilRNAs) and natural antisense transcripts (NATs) are discussed in this review. In summary, we suggest that these ncRNAs might act in coordination to control spermatogenesis and maintain the environmental homeostasis of the testis.
- Subjects
SOMATIC cells; NON-coding RNA; SERTOLI cells; TESTIS; LEYDIG cells
- Publication
Zygote, 2020, Vol 28, Issue 2, p87
- ISSN
0967-1994
- Publication type
Article
- DOI
10.1017/S0967199419000650