We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review.
- Authors
Brignoli, Andrea; Ferrara, Eleonora; Zannetti, Micol; Loi, Gianfranco; Forti, Laura; Socci, Carlo; Carriero, Alessandro; Gennari, Alessandra; Krengli, Marco; Franco, Pierfrancesco
- Abstract
We report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer and provide a comprehensive literature review. This a rare, but life-threatening, clinical situation, that clinicians should be aware of. Severe persistent diarrhea is the most frequent clinical feature and computed tomography is a valid tool for diagnosis. Conservative management includes capecitabine withdrawal, antidiarrheal therapy and endovenous hydration, together with dietary modifications and broad-spectrum antibiotics. Pelvic irradiation represents an adjunctive risk factor, which may increase the likelihood of occurrence of terminal ileitis. Early recognition and prompt intervention are crucial for successful clinical management.
- Subjects
RECTAL cancer; LITERATURE reviews; ILEITIS; CHEMORADIOTHERAPY; COMPUTED tomography; MEDICAL personnel
- Publication
Current Oncology, 2023, Vol 30, Issue 10, p9063
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3390/curroncol30100655