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- Title
Silver-Catalyzed Cross-Coupling of Isocyanides and Active Methylene Compounds by a Radical Process.
- Authors
Liu, Jianquan; Liu, Zhenhua; Liao, Peiqiu; Zhang, Lin; Tu, Tao; Bi, Xihe
- Abstract
Isocyanides are versatile building blocks, and have been extensively exploited in CH functionalization reactions. However, transition-metal-catalyzed direct CH functionalization reactions with isocyanides suffer from over-insertion of isocyanides. Reported herein is a radical coupling/isomerization strategy for the cross-coupling of isocyanides with active methylene compounds through silver-catalysis. The method solves the over-insertion issue and affords a variety of otherwise difficult to synthesize β-aminoenones and tricarbonylmethanes under base- and ligand-free conditions. This report presents a new fundamental CC bond-forming reaction of two basic chemicals.
- Subjects
CARBENES; ISOCYANIDES; COUPLING reactions (Chemistry); ISOMERIZATION; CHEMICAL reactions
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 36, p10618
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201504254