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- Title
The Impact of the Mukaiyama Aldol Reaction in Total Synthesis.
- Authors
Kan, S. B. Jennifer; Ng, Kenneth K.‐H.; Paterson, Ian
- Abstract
Four decades since Mukaiyama's first reports on the successful application of silicon and boron enolates in directed aldol reactions, the ability of this highly controlled carbon-carbon bond-forming method to simultaneously define stereochemistry, introduce complexity, and construct the carbon skeleton with a characteristic 1,3-oxygenation pattern has made it a powerful tool for natural product synthesis. This Minireview highlights a number of representative total syntheses that demonstrate the impact of the Mukaiyama aldol reaction and discusses the underlying mechanistic rationale that determines the stereochemical outcomes.
- Subjects
ALDOLS; SILICON; BORON; ENOLATES; CARBON-carbon bonds; OXYGENATION (Chemistry); STEREOCHEMISTRY
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 35, p9097
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201303914