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- Title
Lymphocyte Aggregation in Low-Grade B-Cell Lymphoma.
- Authors
Walradth, Eric A
- Abstract
Platelet and erythrocyte agglutination is known to happen in vitro due to EDTA or temperature-induced cold antibodies. Leukocyte agglutination is far less common, and its etiology is not always known. The 2 cases presented herein are of low-grade B-cell lymphomas consistent with splenic marginal-zone lymphoma that presented with lymphocyte agglutination. In Case A, the lymphocyte aggregates were not resolved by warming the sample or by non-EDTA anticoagulation. In Case B, the lymphocyte aggregates were largely resolved by warming the specimen at 37°C for 15 minutes. The 2 cases presented herein further show that the etiology of lymphocyte aggregation can have multiple causes, even within the same disease process.
- Subjects
SPLEEN tumors; FLOW cytometry; B cell lymphoma; DIFFERENTIAL diagnosis; ETHYLENEDIAMINETETRAACETIC acid; LEUCOCYTE disorders; LYMPHOCYTE count
- Publication
Laboratory Medicine, 2021, Vol 52, Issue 5, pe133
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmab010