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- Title
Cytosorb ® hemoadsorption of apixaban during emergent cardio-pulmonary bypass: a case report.
- Authors
Mendes, Vitor; Colombier, Sébastien; Verdy, François; Bechtold, Xavier; Schlaepfer, Pierre; Scala, Emmanuelle; Schneider, Antoine; Kirsch, Matthias
- Abstract
Background: Peri-operative coagulation management of patients receiving apixaban, a new oral anticoagulant, is difficult. The CytoSorb® hemoadsorption device might represent a therapeutic option to reduce apixaban's pharmacological and inflammatory effects during high-risk surgery. Case presentation: An 83-year-old woman treated with Apixaban underwent emergent redo mitral valve replacement for prosthetic valve endocarditis. A CytoSorb® cartridge was added to the cardio-pulmonary bypass (CPB) circuit. Apixaban-specific anti-factor Xa activity (AFXaA) were measured peri-operatively. After 100 minutes of CPB, a 50% AFXaA rate decrease was observed as compared to pre-CPB values. Furthermore, we noticed 39% and 44% reductions of AFXaA levels in comparison to the expected levels in patients with normal or altered renal function, respectively. Conclusion: Insertion of a CytoSorb® cartridge in the CPB was safe and associated with rapid correction of Apixaban-associated anticoagulation.
- Subjects
MITRAL valve surgery; HEMOPERFUSION; ANTICOAGULANTS; ENDOCARDITIS; DESCRIPTIVE statistics; CARDIOPULMONARY bypass
- Publication
Perfusion, 2021, Vol 36, Issue 8, p873
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/0267659120967827