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- Title
Cytomegalovirus Retinitis: A Review.
- Authors
Port, Alexander D.; Orlin, Anton; Kiss, Szilard; Patel, Sarju; D'Amico, Donald J.; Gupta, Mrinali P.
- Abstract
Cytomegalovirus (CMV) is a ubiquitous DNA herpes virus that causes significant morbidity and mortality in immunocompromised individuals. CMV retinitis is a potentially blinding manifestation of CMV infection that was commonly seen in advanced acquired immunodeficiency syndrome (AIDS) in the era before modern combination antiretroviral therapy era, but is also recognized in patients with immune deficiency from multiple causes. The advent of and advances in antiretroviral therapies for human immunodeficiency virus have decreased the incidence of CMV retinitis by over 90% among AIDS patients, and improved visual outcomes in those affected. The diagnosis is generally a clinical one, and treatment modalities include systemic and intravitreal antiviral medications. Retinal detachment and immune recovery uveitis are sight-threatening complications of CMV retinitis that require specific treatments.
- Subjects
CYTOMEGALOVIRUS retinitis treatment; ANTIRETROVIRAL agents; DNA viruses; AIDS patients; CLINICAL trials
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2017, Vol 33, Issue 4, p224
- ISSN
1080-7683
- Publication type
journal article
- DOI
10.1089/jop.2016.0140