We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relative risk for cardiovascular morbidity in hemodialysis patients regarding gene polymorphism for IL-10, IL-6, and TNF<sup>1</sup>.
- Authors
Tosic Dragovic, J.; Popovic, J.; Djuric, P.; Jankovic, A.; Bulatovic, A.; Barovic, M.; Pravica, V.; Marinkovic, J.; Dimkovic, N.
- Abstract
Uremia-related inflammation is prone to be a key factor to explain high cardiovascular morbidity in hemodialysis patients. Genetic susceptibility may be of importance, including IL-10, IL-6, and TNF. The aim was to analyze IL-10, IL-6, and TNF gene polymorphisms in a group of hemodialysis patients and to correlate the findings with cardiovascular morbidity. This study included 169 patients on regular hemodialysis at Zvezdara University Medical Center. Gene polymorphisms for IL-10, IL-6 and TNF were determined using PCR. These findings were correlated with the cardiovascular morbidity data from patient histories. Heterozygots for IL-10 gene showed significantly lower incidence of cardiovascular events ( p = 0.05) and twice lower risk for development of myocardial infarction, but experienced twice higher risk for left ventricular hypertrophy. Regarding TNF gene polymorphism, patients with A allele had 1.5-fold higher risk for cerebrovascular accident and cardiovascular events and 2-fold higher risk for hypertension and peripheral vascular disease. Patients with G allele of IL-6 gene experienced 1.5-fold higher risks for cerebrovascular accident. We need studies with larger number of patients for definitive conclusion about the influence of gene polymorphisms on cardiovascular morbidity in hemodialysis patients and its importance in everyday clinical practice.
- Subjects
HEMODIALYSIS patients; GENETIC polymorphisms; INTERLEUKINS; MYOCARDIAL infarction risk factors; HYPERTENSION risk factors; POLYMERASE chain reaction
- Publication
Canadian Journal of Physiology & Pharmacology, 2016, Vol 94, Issue 10, p1106
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2015-0569