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- Title
Response of Discoid and Subacute Cutaneous Lupus Erythematosus to Recombinant Interferon Alpha 2A.
- Authors
Nicolas, Jean-Francois; Thivolet, Jean; Kanitakis, Jean; Lyonnet, Sylvie
- Abstract
Ten patients suffering from discoid lupus erythematosus (DLE) or subacute cutaneous lupus erythematosus (SCLE) were treated with interferon alpha 2a. A marked improvement or clearing of cutaneous lupus erythematosus lesions was observed in eight of them. However, the response to interferon was of short duration and within a few weeks after interferon withdrawal all patients who were improved or cleared relapsed. This study suggests that interferon alpha 2a represents a new interesting approach in the treatment of DLE and SCLE. Ongoing trials will define the optimal treatment schedule for the maintenance of interferon-induced improvement of cutaneous lupus erythematosus.
- Subjects
INTERFERONS; LUPUS erythematosus; ERYTHEMA; CLINICAL trials; SKIN diseases; RECOMBINANT microorganisms
- Publication
Journal of Investigative Dermatology, 1990, Vol 95, p142S
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12875049