We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Agreement between the thromboelastography reaction time parameter using fresh and citrated whole blood during extracorporeal membrane oxygenation with Teg®5000 and Teg®6s.
- Authors
De Falco, Stefano; Meli, Andrea; Caccioppola, Alessio; Grasselli, Giacomo; Panigada, Mauro
- Abstract
Purpose: We aimed at assessing the correlation between TEG reaction time (TEG-R) in citrated and fresh blood samples with TEG5000 and TEG 6S during heparin administration in patients with and without ECMO support. Materials and Methods: Paired TEG5000 (fresh and citrated whole blood, kaolin and kaolin-heparinase) and TEG6S (citrated whole blood) samples were obtained, together with standard coagulation laboratory tests. Bland-Altman analysis and Lin’s concordance correlation coefficient were used to assess agreement. Results: Thirteen consecutive ECMO patients and eight consecutive non-ECMO patients were enrolled and TEG was performed for a total of 84 paired samples. ECMO patients received 19.2 (12.6-25.8) U/kg/h of heparin. Five of the nonECMO patients did not receive heparin, two of them received a very low prophylactic dose (1.6 and 2.9 IU/kg/h, respectively), and one of them 13.1 U/kg/h of heparin. Using TEG®5000, TEG-R was 21.0 (-23.4; 65.5) min longer on fresh compared to citrated blood in patients receiving heparin while only 1.58 (-5.5; 8.7) min longer in patients not-receiving heparin. These differences were reverted by heparinase. Conclusions: Using citrated-recalcified blood to perform TEG might lead to underestimation of the effect of heparin.
- Subjects
PEARSON correlation (Statistics); EXTRACORPOREAL membrane oxygenation; THROMBELASTOGRAPHY; HEPARIN; DESCRIPTIVE statistics; BLOOD coagulation tests; REACTION time; DATA analysis software; HEMOSTASIS; ALGORITHMS
- Publication
Perfusion, 2024, Vol 39, p77S
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/02676591231223085