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- Title
Cost-utility analysis of oral deferasirox versus infusional deferoxamine in transfusion-dependent β-thalassemia patients.
- Authors
Keshtkaran, Ali; Javanbakht, Mehdi; Salavati, Sedigheh; Mashayekhi, Atefeh; Karimi, Mehran; Nuri, Bijan
- Abstract
Background Deferasirox ( DFX) is a novel iron chelator that has been shown to have similar efficacy and safety compared with deferoxamine ( DFO) in patients with β-thalassemia. The aim of this study was to determine the cost utility of DFX versus DFO in β-thalassemia major patients from Iran's society perspective. Study Design and Methods A Markov model has been developed to determine lifetime cost and quality-adjusted life-years ( QALYs) of patients. To estimate the annual cost of each method, a cross-sectional study was conducted among two groups of patients who received DFO and DFX (n = 100 and n = 45, respectively). Also a time trade-off method was used to estimate the utility of two strategies. Finally a one-way and probabilistic sensitivity analysis was conducted to examine the strength of the results. Results Our base-case analysis showed that estimated total lifetime costs per patient for DFX and DFO were 47,029 international dollar ($Int) and $Int143,522, respectively, while the estimated total discounted QALYs per person were 12.28 and 7.76, respectively. Calculated incremental cost-effectiveness ratio showed that DSX is a dominant therapy and its estimated lifetime net monetary benefit was $Int273,528. Conclusion We conclude that the use of DFX instead of DFO represents a cost-effective use of resources for treatment of iron overload in patients with β-thalassemia from Iran's society perspective.
- Subjects
DEFERASIROX; INFUSION therapy; DEFEROXAMINE; BLOOD transfusion; THALASSEMIA; IRON chelates; COMPARATIVE studies; PATIENTS
- Publication
Transfusion, 2013, Vol 53, Issue 8, p1722
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.12024