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- Title
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
- Authors
Jian-Wen Han; Hou-Feng Zheng; Yong Cui; Liang-Dan Sun; Dong-Qing Ye; Zhi Hu; Jin-Hua Xu; Zhi-Ming Cai; Wei Huang; Guo-Ping Zhao; Hong-Fu Xie; Hong Fang; Qian-Jin Lu; Jian-Hua Xu; Xiang-Pei Li; Yun-Feng Pan; Dan-Qi Deng; Fan-Qin Zeng; Zhi-Zhong Ye; Xiao-Yan Zhang
- Abstract
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.23, 10q11.22, 11q23.3 and 16p11.2; 1.77 × 10−25 ≤ Pcombined ≤ 2.77 × 10−8) and confirmed seven previously reported loci (BLK, IRF5, STAT4, TNFAIP3, TNFSF4, 6q21 and 22q11.21; 5.17 × 10−42 ≤ Pcombined ≤ 5.18 × 10−12). Comparison with previous GWAS findings highlighted the genetic heterogeneity of SLE susceptibility between Chinese Han and European populations. This study not only advances our understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.
- Subjects
SYSTEMIC lupus erythematosus; GENOMES; COLLAGEN diseases; AUTOIMMUNE diseases; VASCULAR diseases
- Publication
Nature Genetics, 2009, Vol 41, Issue 11, p1234
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.472