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- Title
Interleukin-15, as Interferon-gamma, Induces the Killing ofLeishmania infantumin Phorbol-Myristate-Acetate-Activated Macrophages Increasing Interleukin-12.
- Authors
D'Agostino, P.; Milano, S.; Arcoleo, F.; Di Bella, G.; La Rosa, M.; Ferlazzo, V.; Caruso, R.; Chifari, N.; Vitale, G.; Mansueto, S.; Cillari, E.
- Abstract
The potential leishmanicidal activity of interleukin-15 (IL-15) was examined while priming with the cytokine phorbol-myristate-acetate (PMA)-activated macrophages and infecting them withLeishmania infantumparasites. The activation of macrophage cultures with IL-15 determined a significant anti-leishmanial activity, comparable with that induced by interferon-gamma (IFN-γ). The killing ofLeishmaniain macrophages primed with IL-15, as well as with IFN-γ, was followed by an increase in the IL-12 synthesis. The neutralization of IL-15 or IFN-γ, by specific monoclonal antibodies (MoAb) caused a significant reduction in leishmanicidal activity. Furthermore, in PMA-activated macrophages, the neutralization of IL-12 production by a specific anti-IL-12 MoAb reduced leishmanicidal activity induced by IL-15 and IFN-γ. Data indicate that IL-15 could have a role as an activator of leishmanicidal activity, directly or indirectly, by inducing IL-12 production.
- Subjects
LEISHMANIASIS; PROTOZOAN diseases; PARASITIC diseases; INTERLEUKINS; GROWTH factors; CYTOKINES
- Publication
Scandinavian Journal of Immunology, 2004, Vol 60, Issue 6, p609
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.0300-9475.2004.01522.x