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- Title
Normal Development of the Gut-Associated Lymphoid Tissue Except Peyer's Patch in MyD88-Deficient Mice.
- Authors
Iiyama, R.; Kanai, T.; Uraushihara, K.; Ishikura, T.; Makita, S.; Totsuka, T.; Yamazaki, M.; Nakamura, T.; Miyata, T.; Yoshida, H.; Takeuchi, O.; Hoshino, K.; Takeda, K.; Ishikawa, H.; Akira, S.; Watanabe, M.
- Abstract
MyD88 is a key adaptor molecule for signalling via Toll-like receptors (TLRs) and the response to gut commensal microbes. To investigate the role of TLRs/MyD88 pathway in the development of the gut-associated lymphoid tissue (GALT), we examined the development of Peyer's patches (PPs) and cryptopatch (CP), and also one of effector compartment, intraepithelial lymphocyte (IEL) in MyD88–/–, TLR2–/– and TLR4–/– mice. In MyD88–/– mice, the organogenesis of PPs was not disturbed. However, PPs in 2-week-old MyD88–/– mice were significantly smaller than those in MyD88+/– mice. Also, in 2-week-old TLR4–/–, but not TLR2–/– mice, PPs did not develop rapidly. The development of PPs in MyD88–/– and TLR4–/– mice was completely recovered in 10 weeks. PP cells from MyD88–/– mice showed significant decrease in proliferation when stimulated with lipopolysaccharide. The development of CP and IEL was also normal in 10-week-old MyD88–/– mice. These results suggest that the TLRs/MyD88 pathway might be involved in the development of PPs only at early postnatal stage, and TLRs/MyD88-independent signalling is critically involved in the development of GALT in adult mice.
- Subjects
CELL receptors; LYMPHOID tissue
- Publication
Scandinavian Journal of Immunology, 2003, Vol 58, Issue 6, p620
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.2003.01346.x