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- Title
T-Cell Regulation of CD5<sup>+</sup> B-Cell Activity in Normal Mice.
- Authors
Huchet, R.; Grandjon, D.; Halle-Pannenko, O.
- Abstract
The differentiation of plaque-forming cell (PFC) precursors against bromelain-treated syngeneic erythrocytes (Br MRBC) into PFC induced in vitro by LPS is down-regulated by nylon non-adherent (nylon-passed -- NP) T cells and by nylon adherent (NA) T cells. NA T cells are more potent inhibitors than NP T cells. This regulatory activity of NA and NP T cells results from an interaction between CD4+ radioresistant and CD8+ radiosensitive T cells, Furthermore CD4+ T cells from the NA fraction but not from the NP fraction are activated cells: their inhibitory activity is abrogated after preincubation with cycloheximide. These results are discussed within the overall framework of T-cell regulation of autoimmune anti-Br MRBC B-cell subsets.
- Subjects
CELLULAR control mechanisms; CELLS; LYMPHOCYTES; T cells; POLYAMIDES; BLOOD cells
- Publication
Scandinavian Journal of Immunology, 1991, Vol 34, Issue 3, p291
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb01549.x