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- Title
The Effects of Interleukins 4 and 5 on the Differentiation of B Cells from (NZBxNZW)F1 Mice.
- Authors
Alarcon-Riquelme, M. E.; Möller, G.; Fernández, C.
- Abstract
We describe here that IL-4 and IL-5 together can induce the production of high amounts of IgG1 polyclonalantibodies by B cells from old (NZB × NZW)F1 miceeven in the absence of LPS. The effect was less marked in young mice from the same strain or in normal Ralb'ce mice. The cells sensitive to the treatment with the interleukins were the large B cells. Old mice had higher proportions of such cells than young mice or normal Balb'c mice, Synthesis of anti-DNA antibodies of the IgM class was induced. Although IL-4 plus IL.-5 induced a strong polyclonal IgG1 production, there were no IgG1 anti-DNA antibodies.
- Subjects
LYMPHOCYTES; MICE; B cells; DNA; NUCLEIC acids; IMMUNOGLOBULINS
- Publication
Scandinavian Journal of Immunology, 1991, Vol 33, Issue 2, p119
- ISSN
0300-9475
- Publication type
Article