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- Title
Separate but Complementary Roles for the Two Forms of Interleukin 1 in the Growth of Transformed Human B Lymphoblasts.
- Authors
Gallagher, G.; Taylor, N.; Willdridge, J.
- Abstract
Epstein-Barr virus (EBV)-transformed human B cells were seeded at densities below their capacity for autostimulatory growth and the effects of interleukin 1-alpha (IL-1-α), interleukin 1-beta(lL-l-β) and B-cell growth factor (BCGF) were studied. When added separately, IL-1-α was able to support the growth of EBV-transformed B cells, as was BCGF. In contrast, IL-1-β was unable to support the growth of these cells but was able to synergize with IL-1-α to promote cell growth. Further, the actions of BCGF and IL-1-α were seen to be synergistic, while those of BCGF and IL-1-β were not. The secretion of immunoglobulin was not affected by these reagents. These findings suggest separate, but complementary roles for the two forms of human IL-1 in B-cell growth.
- Subjects
EPSTEIN-Barr virus; B cells; BIOLOGICAL transport; INTERLEUKIN-1; LYMPHOCYTES; GROWTH factors; MONOKINES
- Publication
Scandinavian Journal of Immunology, 1987, Vol 26, Issue 3, p295
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1987.tb02263.x